Iron (as Iron Amino Acid Chelate) - Iron deficiency has been reported to cause behavioral and developmental symptoms by affecting transmitters such as serotonin, noradrenaline and dopamine, myelination, and the metabolic activity in the neurons. Iron treatment has been thought to increase sleep quality of the patients by decreasing RLS complaints. Multiple clinical studies support this evidence.

Magnesium Citrate - Magnesium is the fourth most abundant mineral in the human body and is involved in hundreds of biochemical reactions. Every cell in your body contains it and needs it to function, but, unfortunately, 50% of people in the U.S. and Europe have suboptimal levels. Magnesium plays a vital role in overall brain function and mood and suboptimal levels have been directly linked to an increased risk of depression. As Healthline reported, "supplementing with this mineral may help reduce symptoms of depression and in some cases, the results can be dramatic."

L-Theanine - L-Theanine is a non-essential amino acid commonly found in black and green tea and plays a fundamental role in maintaining a healthy mental state. L-theanine has shown the ability to reduce stress and anxiety in individuals who are dealing with stressful situations. A study published in the Journal of Clinical Psychiatry that focused on people with Schizophrenia found that L-theanine decreased stress and anxiety and improved Schizophrenia symptoms.

Valerian Root Extract - Valerian root is an herb native to Europe and Asia and is now also grown in the US and China among other countries. Valerian root contains a number of compounds and antioxidants that help promote sleep, ease restlessness, and reduce anxiety. Antioxidants are compounds that inhibit damage to cells by harmful free radicals. Valerian root contains the antioxidants hesperidin and linarin which have sleep-enhancing and calming properties.

Valerian root has a unique interaction with GABA, a chemical messenger that helps regulate nerve impulses in your brain and nervous system. Studies have shown that low levels of GABA are related to chronic stress, anxiety, and low-quality sleep. Valerian root, more specifically, valerenic acid has shown the ability to inhibit the breakdown of GABA in the brain resulting in feelings of calmness and decreased feelings of stress and anxiety.

Passionflower Herb Extract - Passionflower is a climbing-like vine, native to the southeastern United States and Central and South America. Clinical studies show that passionflower has anxiety-calming effects and can effectively help reduce anxiety levels. For example, in one clinical trial, researchers found passionflower had results similar to that of a prescription-based anti-anxiety medication. In fact, certain studies suggest passionflower may work as effectively as some anxiety prescription medication. Additionally, a 2016 clinical trial found that passionflower decreased anxiety and improved memory in the participants. Two other clinical trials found that passionflower has sedative effects. These effects could be due, in part, to passionflower interacting with GABA levels in the brain.

Melatonin - Melatonin is a hormone naturally made by your body and is produced in the brain by the pineal gland. Melatonin works together with your body's circadian rhythm—which is your body's internal clock and lets you know when it is time to sleep, wake up, and eat.

Take 2 Easy Sleep™ capsules 1 hour before bed for a restful, restorative sleep.

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Disease Risk - 65 reports

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Cancer risk - 36 reports

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Drug response - 103 reports

Autism is widespread and the number of children diagnosed with it is increasing at a rate of between 10 and 17 percent annually. Today one in every 68 children is diagnosed with autism, making it more prevalent than childhood cancer, juvenile diabetes, and childhood AIDS combined. Autism spectrum disorder (ASD) refers to a group of brain development disorders that affect communication skills and social interaction to varying degrees of intensity.

Recent studies have shown children with autism have immune dysregulation and increased inflammation. Because the immune and nervous systems are closely interconnected, several immunological abnormalities have been detected in the nervous system of autistic children. Inflammatory compounds have also been found in the brains and bloodstream of autistic children.

Curcumin - Curcumin is a bright yellow (orange) chemical produced by curcuma long plants which are extensively cultivated in the tropical and subtropical regions of Southeast Asia including China, India, and Indonesia. Curcumin has extremely powerful antioxidant and anti-inflammatory effects. Research has shown that curcumin activates certain proteins, including sirloins and AMP-activated protein kinase (AMPk), which can delay cellular senescence and promote longevity. Cellular senescence refers to, "a state of stable cell cycle arrest in which proliferating cells become resistant to growth—promoting stimuli, typically in response to DNA damage." Studies show that curcumim can restore the core and associated symptoms of autistic phenotype by suppressing oxidative-nitrosative stress, mitochondrial dysfunction, TNF-α and MMP-9 in PPA-induced autistic children.

Quercetin - Quercetin is a natural plant pigment and is one of the most abundant antioxidants in the human diet and plays a vital role in helping your body combat free radical damage. Free radicals are unstable atoms that can damage cells, causing illness and premature aging. Quercetin is present in fruits, vegetables, and grains.

Resveratrol - Resveratrol, like curcumin, is a polyphenol that acts like an antioxidant, helping protect the body against oxidative damage that can put you at a higher risk for cancer and heart disease. Resveratrol has gained in popularity for its reported anti-aging and disease fighting power. The top food sources of reseveratrol include red wine, grapes, and some berries.

Magnesium Citrate - Magnesium is the fourth most abundant mineral in the human body and is involved in hundreds of biochemical reactions. Every cell in your body contains it and needs it to function, but, unfortunately, 50% of people in the U.S. and Europe have suboptimal levels. Magnesium plays a vital role in overall brain function and mood and suboptimal levels have been directly linked to an increased risk of depression.

Glutathione - Glutathione is a substance produced naturally by the liver. It is also found in fruits, vegetables, and meats. Glutathione is involved in many processes in the body, including tissue building and repair, making chemicals and proteins needed in the body, and for the immune system.

Piperine - Piperine is a major alkaloid (class of basic, naturally occurring compounds that contain at least one nitrogen atom) found in black pepper and is widely used for its purported anti-inflammatory, antioxidant, and anti-tumor properties. Piperine has been shown to protect against oxidative damage by inhibiting free radicals (atoms or molecules that are unstable with other cellular structures because they contain unpaired electrons) and reactive oxygen species. Interestingly, piperine can also increase the absorption of curcumin by up to 2,000%.

Vitamin C - Vitamin C is an essential vitamin, meaning your body can’t produce it. Yet, it has many roles and has been linked to impressive health benefits. It’s water-soluble and found in many fruits and vegetables, including oranges, strawberries, kiwi fruit, bell peppers, broccoli, kale, and spinach. Vitamin C is a powerful antioxidant that can strengthen your body’s natural defenses. Antioxidants are molecules that boost the immune system. They do so by protecting cells from harmful molecules called free radicals. When free radicals accumulate, they can promote a state known as oxidative stress, which has been linked to many chronic diseases.

Zinc - Zinc is a nutrient that plays many vital roles in your body. Because your body doesn’t naturally produce zinc, you must obtain it through food or supplements. Zinc is required for numerous processes in your body, including:

• Gene expression

• Enzymatic reactions

• Immune function

• Protein synthesis

• DNA synthesis

• Wound healing

• Growth and development

Selenium - Though you may have never heard of selenium, this amazing nutrient is vital to your health. Selenium is an essential mineral, meaning it must be obtained through your diet. Selenium acts as a powerful antioxidant and can help reduce inflammation throughout the entire body. In addition, selenium can help prevent mental decline and significantly boost immune system function.

Stem cells are cells with the potential to develop into many different types of cells in the body. Stem cells act as a repair system for the body and rejuvenate and replace aging cells to maintain health. These cells reside throughout the body in an “inactive” state until injury or inflammation occur. Recently stem cells have been studied for anti-aging effects, reversing blindness, regenerating cartilage, etc.

A study showed the effect of Stemulife™ on fat derived stem cells of a patient taking Stemulife™, compared to others (Patient A & Patient B) who did not take any “activating supplements.” The patient taking Stemulife™ had a 10x increase of healthy cells with an increase in cellular energy, and 2x faster stem cell growth rate.

Piperine - Piperine is a major alkaloid (class of basic, naturally occurring compounds that contain at least one nitrogen atom) found in black pepper and is widely used for its purported anti-inflammatory, antioxidant, and anti-tumor properties. Piperine has been shown to protect against oxidative damage by inhibiting free radicals (atoms or molecules that are unstable with other cellular structures because they contain unpaired electrons) and reactive oxygen species.

Curcumin - Curcumin is a polyphenol (micronutrients we get through certain plant-based foods) with anti-inflammatory properties primarily found in turmeric. Despite its reported benefits via inflammatory and antioxidant mechanisms, one of the major problems with ingesting curcumin by itself is its poor bioavailability. Piperine, however, a major active component of black pepper [16] and a key ingredient in Stemulife™ is associated with an increase of 2000% in the bioavailability of curcumin.

Quercetin - Quercetin is a natural plant pigment and is one of the most abundant antioxidants in the human diet and plays a vital role in helping your body combat free radical damage. Quercetin is present in fruits, vegetables, and grains.

Resveratrol - Resveratrol, like curcumin, is a polyphenol that acts like an antioxidant, helping protect the body against oxidative damage that can put you at a higher risk for cancer and heart disease. Resveratrol has gained in popularity for its reported anti-aging and disease fighting power. The top food sources of reseveratrol include red wine, grapes, and some berries.

COQ10 - CoQ10, also known as Coenzyme Q10 is an antioxidant that your body naturally produces, however, levels of CoQ10 in your body decrease as you age. Preliminary studies have displayed that CoQ10 may in fact slow, but not necessarily stop, the progression of Alzheimer's disease. CoQ10 has also been studied as a preventive treatment of migraine headaches and has also used to treat heart failure and other heart conditions.

Tocotrienol - Both tocotrienols and tocopherols may be referred to as vitamin E. Vitamin E is an antioxidant, meaning it helps neutralize free radicals. Free radicals are chemicals related to a host of health issues, including skin aging, cancer, chronic inflammation, and numerous diseases.

200 Mg Magnesium Citrate - Magnesium is the fourth most abundant mineral in the human body and is involved in hundreds of biochemical reactions. Every cell in your body contains it and needs it to function, but, unfortunately, 50% of people in the U.S. and Europe have suboptimal levels. Magnesium plays a vital role in overall brain function and mood and suboptimal levels have been directly linked to an increased risk of depression. As Healthline reported, "supplementing with this mineral may help reduce symptoms of depression and in some cases, the results can be dramatic."

200 Mg L-Theanine - L-Theanine is a non-essential amino acid commonly found in black and green tea and plays a fundamental role in maintaining a healthy mental state. L-theanine has shown the ability to reduce stress and anxiety in individuals who are dealing with stressful situations. A study published in the Journal of Clinical Psychiatry that focused on people with Schizophrenia found that L-theanine decreased stress and anxiety and improved Schizophrenia symptoms.

100 Mg 5 HTP (Griffonia Simplicifolia Seed Extract) - L 5-Hydroxytryptophan (5-HTP) is an amino acid that your body naturally produces. Your body uses 5-HTP to produce serotonin, a chemical that has a variety of functions in the human body. It is often refered to as the happy chemical because it contributes to overall well-being and happiness.The positive benefits of 5-HTP on the symptoms of depression has been extensively studied over the years and research has found that 5-HTP nutraceuticals are thought to help treat depression as well as stress and anxiety by increasing serotonin levels.

750 Mg Ashwagandha Root Extract 4:1 (Withania Somnifera)- Ashwagandha is an ancient medicinal herb that is classified as an adaptogen, meaning it can help the body manage stress and has been around for over 3,000 years to treat a variety of conditions including stress, anxiety, depression, and even cognitive decline.

100 Mg Rhodiola Rosea Extract 4:1 - Rhodiola rosea is a flowering herb grown in the cold, high-altitude regions of Europe and Asia. Rhodiola has been used in traditional medicine for thousands of years to help treat anxiety, stress, depression, and fatigue. As Kamal Patel, who is the founder of Examine.com stated, "Rhodiola appears to be able to significantly reduce the fatigue and 'burnout' that come from stress and anxiety; numerous trials suggest meaningful effects, particularly in people with stress and anxiety issues."

Take 2 all-natural Thought Calmer™ capsules in the morning with your breakfast, coffee, or tea for all day stress and anxiety relief. Each Thought Calmer™ bottle comes with 60 capsules for exactly 30 stress-free servings.