It seems likely that epigenetic dysregulation might contribute to significant proportion of ASD cases. Many environmental factors that have epidemiological association with ASDs (autism spectrum disorders) exert their effects through epigenetic alterations. In addition, significant correlations between DNA methylation and quantitatively measured autistic trait scores were also identified, suggesting quantitative relationship between the severity of the autistic phenotype and epigenetic variation at several multiple loci previously implicated in the pathogenesis of ASDs, including AFF2, AUTS2, GABRB3, NLGN3, NRXN1, SLC6A4 and UBE3A.
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